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Filtered Search Results
Aobchem AOBCHEM
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5000430628 LENTIVIRUS SOLUTION 100ML
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000430629 MITOCHONDRIA ISOLATI 100T
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000430729 VARI FLUOR 594-PHALL 300T
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Aobchem AOBCHEM
5000865645 1-BROMO-3 5-DICHLORO-2-METHYLB
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Apexbio Technology LLC EI1 1418308-27-6 25mg
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EI1 (CAS 1418308-27-6) is a potent and selective small-molecule inhibitor of the histone methyltransferase Ezh2 demonstrating IC50 values of 15 nM against wild-type Ezh2 and 13 nM for the Y641F mutant Ezh2 is implicated in oncogenesis through epigenetic silencing of tumor suppressor genes and is frequently upregulated or mutated in various cancers In cellular studies EI1 inhibits H3K27 methylation and induces expression of Ezh2 target genes such as p16 It effectively impedes the proliferation of DLBCL cells particularly those harboring EZH2 mutations leading to cell cycle arrest and apoptosis EI1 is widely used to investigate Ezh2 function and its role in cancer biology
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Apexbio Technology LLC CC-223 1228013-30-6 25mg
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CC-223 (CAS 1228013-30-6) is an orally bioavailable ATP-competitive inhibitor of mTOR kinase exhibiting potent activity with an IC50 of 16 nM It directly targets both mTORC1 and mTORC2 complexes effectively blocking downstream phosphorylation events including those mediated by 4EBP1 p70 S6 kinase and AKT CC-223 demonstrates high selectivity for mTOR over related kinases such as PI3K In preclinical studies CC-223 inhibited proliferation in various non-Hodgkin lymphoma and solid tumor cell lines including glioma breast hepatic and non-small cell lung cancers In vivo it produced dose- and schedule-dependent tumor growth inhibition in PC-3 xenograft models CC-223 has also shown tolerability and preliminary antitumor activity in early-phase clinical evaluations
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Medchemexpress LLC L-5-Hydroxytryptophan | 4350-09-8 | 99.99% | 25 G
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L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and dietary supplement, is used as an antidepressant, appetite suppressant, and sleep aid. It serves as the immediate precursor of the neurotransmitter serotonin and acts as a reserpine antagonist. It is also utilized in the treatment of fibromyalgia, myoclonus, migraine, and cerebellar ataxia.
- Endogenous metabolite
- Naturally occurring amino acid
- Dietary supplement
- Precursor of neurotransmitter serotonin
- Reserpine antagonist
- Used for research purposes only; not sold to patients
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Medchemexpress LLC Chlorahololide C | 1007859-25-7 | 1 MG
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Chlorahololide C is a lindenane sesquiterpenoid dimer isolated from *Chloranthus holostegius*. It functions as a potent and selective potassium channel blocker, with an IC50 of 3.6 μM. For research use only. In vitro, Chlorahololide C (0.1-100 μM) inhibits the delayed rectifier K+ current (IK) in rat dissociated hippocampal neurons, with an IC50 of 3.6 μM.
- Molecular weight: 576.63
- Formula: C33H36O9
- Appearance: Solid
- Color: White to off-white
- Purity: 98.0%
- Structure classification: Terpenoids, sesquiterpenes
- Initial source: Plants, Chloranthaceae, *Chloranthus holostegius* (Hand.-Mazz.) Pei et Shan
- Potent and selective potassium channel blocker
- Suitable for research applications
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Apexbio Technology LLC L-AP5 79055-67-7 50mg
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L-AP5 (CAS 79055-67-7) is a selective antagonist of the N-methyl-D-aspartate (NMDA) receptor a subtype of ionotropic glutamate receptors By competitively inhibiting NMDA receptor activation L-AP5 prevents glutamate-induced calcium influx into neurons thereby modulating excitatory neurotransmission within the central nervous system This compound is widely utilized in neurobiological research to investigate the physiological and pathological roles of NMDA receptor-mediated signaling particularly in studies related to neuroprotection and neuropathological conditions
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Apexbio Technology LLC Deoxyguanosine 5-triphosphate 93919-41-6 10mg
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Deoxyguanosine 5-triphosphate (CAS 93919-41-6) is a nucleotide analogue that serves as a precursor for DNA synthesis within cells It functions as a substrate for reverse transcriptase facilitating the incorporation of guanine residues during DNA chain elongation Experimental studies demonstrate that its presence enhances DNA amplification efficiency in reverse transcription polymerase chain reaction (RT-PCR) assays Due to these properties Deoxyguanosine 5-triphosphate is widely utilized as a molecular reagent in genomic research and molecular diagnostics supporting investigations into nucleic acid metabolism and gene expression analysis
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Apexbio Technology LLC Adenosine 5-monophosphate 61-19-8 500mg
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Adenosine 5 -monophosphate (AMP) is a nucleotide composed of the adenosine nucleoside esterified with a single phosphate group Serving as an intermediate in cellular energy metabolism AMP is involved in various biochemical pathways including the regulation of enzyme activity and signal transduction processes It plays a pivotal role in modulating the AMP-activated protein kinase (AMPK) pathway which governs cellular energy homeostasis AMP is widely utilized in research settings to study metabolic regulation nucleotide signaling and enzymatic reactions associated with phosphorylation and cellular energy status
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